Many patients will notice that their skin appears red or tan after their VI Peel treatment, which is normal and will subside shortly after the procedure. Patients can return to regular activities immediately after their appointment; however, the peel solution must stay on the face for five hours, and strenuous activities, such as exercise, should be avoided until the patient washes the solution off. Patients can apply make-up prior to and after the peeling process, but should not wear make-up while their skin is peeling.

The peeling process most often begins on the third day after the procedure and can last from a few days to one week. During the peeling period, patients may have some sensitivity and should avoid sun exposure as much as possible. Moisturizer can be used during this time to mask the light, feathery skin peeling if the patient is concerned about the appearance of their skin.